5-Bromo-DMT (5-bromo-N,N-dimethyltryptamine) is a psychedelic brominated indole alkaloid found in the sponges Smenospongia aurea and Smenospongia echina, as well as in Verongula rigida (0.00142% dry weight) alongside 5,6-Dibromo-DMT (0.35% dry weight) and seven other alkaloids. It is the 5-bromo derivative of DMT, a psychedelic found in many plants and animals.
This research chemical has a EC50 value of 5.51 for the 5-HT2A receptor.
Animal studies on 5-Bromo-DMT showed that it produces effects suggestive of sedative and antidepressant activity. Also, it causes significant reduction of locomotor activity in the rodent FST model.
Thus, it was reported to be psychoactive at 20–50 mg via vaporization with mild psychedelic-like activity.