This chemical (also known as 4-FMA) is a lesser-known novel stimulant-entactogen substance of the amphetamine class. 4-FMA is chemically related to 4-FA and methamphetamine. Little is known about its pharmacology, but it likely produces its effects by increasing levels of dopamine, norepinephrine, and serotonin in the brain.
4-FMA was first detected being sold in Japan as a legal high in 2006. It has been sold online as a research chemical alongside 2-fluoroamphetamine (2-FA), 3-fluoroamphetamine (3-FA) and 4-fluoroamphetamine (4-FA). When 4-FA was made illegal in the Netherlands in 2017, 4-FMA grew in popularity as a legal substitute, due to their similar names and effects. In 2018, the number of analyzed 4-FA samples increasingly contained 4-FMA (and/or other fluorinated amphetamines) and the availability of actual 4-FA decreased sharply. 4-Fluoromethamphetamine (hydrochloride)
User reports describe the effects of 4-FMA as having characteristics of both traditional stimulants like amphetamine and entactogens like MDMA. Its effects have been described as subjectively lying between 4-FA and 2-FMA. It has been reported to be more likely to produce side effects like headaches and cardiovascular effects than similar substances.
Very little is known about the pharmacological properties, metabolism, and toxicity of 4-FMA. 4-FMA use may produce dependence and abuse as well as damage to the brain and other organs. It is highly advised to use harm reduction practices if using this substance.